Name: AG-13958 monohydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT218852172
Cas No:319463-49-5
常用名:AG-13958 monohydrochloride
IUPAC:N-[2-fluoro-5-({3-[(1E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}amino)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide hydrochloride
IUPAC:N-[2-fluoro-5-({3-[(1E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}amino)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide hydrochloride
InChI key:BRTPJWBYMBBEHE-YGCVIUNWSA-N

分子式:C26H23ClFN7O
分子量:503.97
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.Cc1cc(C(=O)Nc2cc(Nc3ccc4c(\C=C\c5ccccn5)n[nH]c4c3)ccc2F)n(C)n1
SMILES:Cl.Cc1cc(C(=O)Nc2cc(Nc3ccc4c(\C=C\c5ccccn5)n[nH]c4c3)ccc2F)n(C)n1

AG-13958 monohydrochloride is the HCl salt of AG-13958 --- a VEGFA inhibitor potentially for the treatment of age-related macular degeneration. Neovascular AMD, a subtype characterized by the growth of new, pathologic blood vessels, results in most of the cases of severe and rapid vision loss associated with AMD. A critical activator of angiogenesis in neovascular AMD is VEGF.

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