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  3. HIT218852174
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HIT218852174
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HIT218852174
  • HIT ID:HIT218852174
  • Cas No:2775365-40-5
  • 常用名:Bexotegrast HCl
  • IUPAC:(2S)-4-[(2-methoxyethyl)[4-(1,5,6,7-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]-2-[(quinazolin-4-yl)amino]butanoic acid dihydrochloride
    IUPAC:(2S)-4-[(2-methoxyethyl)[4-(1,5,6,7-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]-2-[(quinazolin-4-yl)amino]butanoic acid dihydrochloride
  • InChI key:VKZGWNHLIIVREO-ASMAMLKCSA-N
  • 分子式:C27H38Cl2N6O3
  • 分子量:565.54
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Cl.Cl.COCCN(CCCCC1=CC=C2CCCN=C2N1)CC[C@H](Nc1ncnc2ccccc12)C(O)=O
    SMILES:Cl.Cl.COCCN(CCCCC1=CC=C2CCCN=C2N1)CC[C@H](Nc1ncnc2ccccc12)C(O)=O
  • Bexotegrast, also known as PLN-74809, is a small-molecule, dual selective inhibitor of αVβ1 / αVβ6 for idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). These integrins cause upstream activation of TGF-β1 in actively fibrotic tissue. Inhibition of these integrins will block TGF-β1 activation, thereby preventing the growth of fibrotic tissue within the lung and bile ducts.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    8-10周
    纯度
    -
    ¥ 15,000.00
    1

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