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  3. HIT218852195
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HIT218852195
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HIT218852195
  • HIT ID:HIT218852195
  • Cas No:2378280-82-9
  • 常用名:GS-441524 HCl
  • IUPAC:(2R,3R,4S,5R)-2-{4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl}-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile hydrochloride
    IUPAC:(2R,3R,4S,5R)-2-{4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl}-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile hydrochloride
  • InChI key:RUKJXQWRCFJDMA-BITRNDABSA-N
  • 分子式:C12H14ClN5O4
  • 分子量:327.73
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Cl.Nc1ncnn2c(ccc12)[C@@]1(O[C@H](CO)[C@@H](O)[C@H]1O)C#N
    SMILES:Cl.Nc1ncnn2c(ccc12)[C@@]1(O[C@H](CO)[C@@H](O)[C@H]1O)C#N
  • GS-441524 is a potent inhibitor of feline infectious peritonitis (FIP) virus with an EC50 of 0.78 μM.. GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. GS-441524 was non-toxic in feline cells at concentrations as high as 100 uM and effectively inhibited FIPV replication in cultured CRFK cells and in naturally infected feline peritoneal macrophages at concentrations as low as 1 uM. Note: GS-441524 is an active metabolite of Remdesivir.
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  • 供应商
    TargetMolSC
    规格
    货期
    1-2周
    纯度
    -
    ¥ 10,600.00
    1

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