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  3. HIT218852199
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HIT218852199
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HIT218852199
  • HIT ID:HIT218852199
  • Cas No:2351884-03-0
  • 常用名:SR1903 TFA
  • IUPAC:1,1,1,3,3,3-hexafluoro-2-[2'-methyl-4'-({4-[(pyridin-4-yl)methyl]piperazin-1-yl}methyl)-[1,1'-biphenyl]-4-yl]propan-2-ol; trifluoroacetic acid
    IUPAC:1,1,1,3,3,3-hexafluoro-2-[2'-methyl-4'-({4-[(pyridin-4-yl)methyl]piperazin-1-yl}methyl)-[1,1'-biphenyl]-4-yl]propan-2-ol; trifluoroacetic acid
  • InChI key:QBVZDSMHTOGPNF-UHFFFAOYSA-N
  • 分子式:C29H28F9N3O3
  • 分子量:637.547
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:OC(=O)C(F)(F)F.Cc1cc(CN2CCN(Cc3ccncc3)CC2)ccc1-c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
    SMILES:OC(=O)C(F)(F)F.Cc1cc(CN2CCN(Cc3ccncc3)CC2)ccc1-c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
  • SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor γ (PPAR) but does not activate it. SR-1903 inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1). It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1. SR-1903 reduces the severity of collagen-induced arthritis. It reduces blood glucose levels in a glucose tolerance test, serum levels of total cholesterol and LDL, body weight, and fat mass in a mouse model of high-fat diet-induced obesity.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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