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  3. HIT218852200
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HIT218852200
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HIT218852200
  • HIT ID:HIT218852200
  • Cas No:2320261-63-8
  • 常用名:AEW541 HCl
  • IUPAC:5-[3-(benzyloxy)phenyl]-7-[(1s,3s)-3-[(azetidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine dihydrochloride
    IUPAC:5-[3-(benzyloxy)phenyl]-7-[(1s,3s)-3-[(azetidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine dihydrochloride
  • InChI key:XBUCKSAZHWFXGF-DBEIMXIDSA-N
  • 分子式:C27H31Cl2N5O
  • 分子量:512.48
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Cl.Cl.Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCC2)C1
    SMILES:Cl.Cl.Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCC2)C1
  • AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP- AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. Note: AEW541 has a Cis-configuration on the cyclobutane ring. Its CAS# is 475489-16-8. Many vendors and Sc-finder scholar made mistake - AEW541 was mistakenly listed as CAS#475488-34-7, the trans-isomer of AEW541. The correct structure of AEW541 can be confirmed from Joel Slade, et al (from Novartis), Org. Process Res. Dev. 2007, 11, 5, 825–835.
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    TargetMolSC
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    ¥ 2,870.00
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