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  3. HIT218852210
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HIT218852210
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HIT218852210
  • HIT ID:HIT218852210
  • Cas No:1160589-73-0
  • 常用名:CHS-828 nicotinate
  • IUPAC:N-[6-(4-chlorophenoxy)hexyl]-N'-cyano-N''-(pyridin-4-yl)guanidine; pyridine-3-carboxylic acid
    IUPAC:N-[6-(4-chlorophenoxy)hexyl]-N'-cyano-N''-(pyridin-4-yl)guanidine; pyridine-3-carboxylic acid
  • InChI key:SUDJZJKHKVJACX-UHFFFAOYSA-N
  • 分子式:C25H27ClN6O3
  • 分子量:494.98
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:OC(=O)c1cccnc1.Clc1ccc(OCCCCCCNC(NC#N)=Nc2ccncc2)cc1
    SMILES:OC(=O)c1cccnc1.Clc1ccc(OCCCCCCNC(NC#N)=Nc2ccncc2)cc1
  • CHS-828 nicotinate is a CHS-828 salt with Nicotinic acid.. CHS-828 also known as GMX-1778, is a potent and selective NAMPT inhibitor. CHS-828 inhibits cellular synthesis of NAD. CHS 828 kill tumour cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome. CHS 828 has shown promising anticancer activity in experimental tumor models and primary cultures of cancer cells from patients. CHS 828 showed a synergistic effect with melphalan in 67%, doxorubicin in 47%, etoposide in 38% and Ara-C in 14% of AML samples.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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