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  3. HIT218852233
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HIT218852233
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HIT218852233
  • HIT ID:HIT218852233
  • Cas No:111922-05-5
  • 常用名:Noberastine maleate
  • IUPAC:bis((2Z)-but-2-enedioic acid); N-{3-[(5-methylfuran-2-yl)methyl]-3H-imidazo[4,5-b]pyridin-2-yl}piperidin-4-amine
    IUPAC:bis((2Z)-but-2-enedioic acid); N-{3-[(5-methylfuran-2-yl)methyl]-3H-imidazo[4,5-b]pyridin-2-yl}piperidin-4-amine
  • InChI key:YBWFIFFZTNIWTM-SPIKMXEPSA-N
  • 分子式:C25H29N5O9
  • 分子量:543.533
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.Cc1ccc(Cn2c(NC3CCNCC3)nc3cccnc23)o1
    SMILES:OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.Cc1ccc(Cn2c(NC3CCNCC3)nc3cccnc23)o1
  • Noberastine maleate, a histamine H1 antagonist, has potent and specific peripheral antihistaminic activity. Noberastine, a furan derivative of nor-astemizole (an astemizole metabolite), has been shown to have a more rapid onset, and shorter duration of action than astemizole with peak antihistaminic activity at 4h following ingestion. Noberastine is rapidly absorbed and the peak plasma levels are obtained within 2 h of oral dosing. In preclinical studies Noberastine has been shown to lack central nervous system effects. After subacute (steady-state) administration of noberastine, there was increasing inhibition of weal and flare formation with higher doses of the drug. The 30 mg daily dose showed maximum antihistaminic effects.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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