• CAS号
  • HIT ID
  • 供应商货号
  • SMILES
  • 化合物库

购物车
0
  2. 结构式搜索
  3. HIT218852242
有库存
HIT218852242
 sdf 文件
结构编辑
类似物检索
HIT218852242
  • HIT ID:HIT218852242
  • Cas No:1084896-50-3
  • 常用名:Afegostat TFA
  • IUPAC:(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol; trifluoroacetic acid
    IUPAC:(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol; trifluoroacetic acid
  • InChI key:PNXZXZUWUKJXBH-RWOHWRPJSA-N
  • 分子式:C8H14F3NO5
  • 分子量:261.197
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:OC(=O)C(F)(F)F.OC[C@H]1CNC[C@@H](O)[C@@H]1O
    SMILES:OC(=O)C(F)(F)F.OC[C@H]1CNC[C@@H](O)[C@@H]1O
  • Afegostat, aslo known as Isofagomine, and AT2101, was an experimental drug for the treatment of certain forms of Gaucher's disease. Isofagomine (IFG) is an acid β-glucosidase (GCase) active site inhibitor that acts as a pharmacological chaperone. FG inhibits GCase with K(i) ~30 nM for wild-type and mutant enzymes (N370S and V394L). Administration of IFG (30 mg/kg/day) to the mice homozygous for GCase mutations (V394L, D409H, or D409V) led to increased GCase activity in visceral tissues and brain extracts.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

寻找合适的化合物库

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。
电话：400820-0310
合作：info@screeningcompound.com
技术支持：tech@screeningcompound.com
客服：service@screeningcompound.com
TargetMol | Target Loading
正在加载 ~
常用功能
使用指南化合物搜索在线客服返回顶层