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HIT218852380
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HIT218852380
  • HIT ID:HIT218852380
  • Cas No:343322-50-9
  • 常用名:GW590735 sodium
  • IUPAC:sodium 2-methyl-2-{4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}formamido)methyl]phenoxy}propanoate
    IUPAC:sodium 2-methyl-2-{4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}formamido)methyl]phenoxy}propanoate
  • InChI key:RKWLGVFEDFICPQ-UHFFFAOYSA-M
  • 分子式:C23H20F3N2NaO4S
  • 分子量:500.47
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:[Na+].Cc1nc(sc1C(=O)NCc1ccc(OC(C)(C)C([O-])=O)cc1)-c1ccc(cc1)C(F)(F)F
    SMILES:[Na+].Cc1nc(sc1C(=O)NCc1ccc(OC(C)(C)C([O-])=O)cc1)-c1ccc(cc1)C(F)(F)F
  • GW590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ. GW590735 significantly increased HDL cholesterol, decreased LDL and VLDL cholesterol, and significantly reduced triglycerides. Maximal increases in HDL cholesterol were 37%, 53%, and 84% with fenofibrate, torcetrapib, and GW590735, respectively.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    1-2周
    纯度
    -
    ¥ 10,600.00
    1

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