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HIT218852382
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HIT218852382
  • HIT ID:HIT218852382
  • Cas No:247584-21-0
  • 常用名:AWD12-281 sodium
  • IUPAC:sodium 3-{[(3,5-dichloropyridin-4-yl)carbamoyl]carbonyl}-1-[(4-fluorophenyl)methyl]-1H-indol-5-olate
    IUPAC:sodium 3-{[(3,5-dichloropyridin-4-yl)carbamoyl]carbonyl}-1-[(4-fluorophenyl)methyl]-1H-indol-5-olate
  • InChI key:AFQFMQPOEHZPEI-UHFFFAOYSA-M
  • 分子式:C22H13Cl2FN3NaO3
  • 分子量:480.25
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:[Na+].[O-]c1ccc2n(Cc3ccc(F)cc3)cc(C(=O)C(=O)Nc3c(Cl)cncc3Cl)c2c1
    SMILES:[Na+].[O-]c1ccc2n(Cc3ccc(F)cc3)cc(C(=O)C(=O)Nc3c(Cl)cncc3Cl)c2c1
  • AWD 12-281 is a selective phosphodiesterase 4 (PDE4) inhibitor for the treatment of lung inflammation using inhalative administration. AWD 12-281 Is Active in a New Guinea-Pig Model of Allergic Skin Inflammation Predictive of Human Skin Penetration and Suppresses Both Th1 and Th2 Cytokines in Mice. AWD 12-281 is a very promising drug candidate not only for the treatment of lung inflammation using inhalative administration but also for the treatment of atopic dermatitis.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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