Name: Etoposide phosphate disodium
Rating: 5 (10 reviews)

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HIT ID:HIT218886923
Cas No:
常用名:Etoposide phosphate disodium
别名:Etoposide phosphate disodium, BMY-40481 disodium
别名:Etoposide phosphate disodium, BMY-40481 disodium
IUPAC:disodium 4-[(10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-12-oxo-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1,3(7),8-trien-10-yl]-2,6-dimethoxyphenyl phosphate
IUPAC:disodium 4-[(10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-12-oxo-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1,3(7),8-trien-10-yl]-2,6-dimethoxyphenyl phosphate
InChI key:WCOHVOKFXMNYJU-XIYZZTPRSA-L

分子式:C29H31Na2O16P
分子量:712.504
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[Na+].[Na+].[H][C@]12COC(=O)[C@]1([H])[C@H](c1cc(OC)c(OP([O-])([O-])=O)c(OC)c1)c1cc3OCOc3cc1[C@H]2O[C@@H]1O[C@]2([H])CO[C@@H](C)O[C@@]2([H])[C@H](O)[C@H]1O
SMILES:[Na+].[Na+].[H][C@]12COC(=O)[C@]1([H])[C@H](c1cc(OC)c(OP([O-])([O-])=O)c(OC)c1)c1cc3OCOc3cc1[C@H]2O[C@@H]1O[C@]2([H])CO[C@@H](C)O[C@@]2([H])[C@H](O)[C@H]1O

Etoposide phosphate disodium (BMY-40481 disodium), a phosphate ester prodrug of etoposide, functions as a potent chemotherapeutic agent by selectively inhibiting topoisomerase II, hindering the re-ligation of DNA strands. It is regarded as the active equivalent of etoposide, effectively inducing cell cycle arrest, apoptosis, and autophagy in cancer cells.

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