Name: TQ05310
Rating: 5 (10 reviews)

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HIT ID:HIT218903697
Cas No:2071196-10-4
常用名:TQ05310
别名:TQ-05310
IUPAC:4-[(tert-butoxy)imino]-6-[6-(trifluoromethyl)pyridin-2-yl]-N-[2-(trifluoromethyl)pyridin-4-yl]-1,4-dihydro-1,3,5-triazin-2-amine
IUPAC:4-[(tert-butoxy)imino]-6-[6-(trifluoromethyl)pyridin-2-yl]-N-[2-(trifluoromethyl)pyridin-4-yl]-1,4-dihydro-1,3,5-triazin-2-amine
InChI key:NBWCZHZMPHWJIO-UHFFFAOYSA-N

分子式:C19H17F6N7O
分子量:473.383
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)(C)ON=c1nc(Nc2ccnc(c2)C(F)(F)F)[nH]c(n1)-c1cccc(n1)C(F)(F)F
SMILES:CC(C)(C)ON=c1nc(Nc2ccnc(c2)C(F)(F)F)[nH]c(n1)-c1cccc(n1)C(F)(F)F

TQ05310为口服活性的IDH2突变型抑制剂，特异性针对IDH2-R140Q (IC50=136.9 nM)及IDH2-R172K (IC50=37.9 nM)两种突变体。该化合物通过抑制突变IDH2的酶活性以降低2-羟戊二酸(2-HG)的生成，进而诱导携带IDH2-R140Q和IDH2-R172K突变的细胞分化。此外，TQ05310亦被应用于急性髓系白血病的相关研究。

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