Name: Sabialimon P
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT218903921
Cas No:2267333-96-8
常用名:Sabialimon P
IUPAC:methyl (4aS,6aS,6bR,8aS,10S,12S,12aR,12bS,14bS)-10,12-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate
IUPAC:methyl (4aS,6aS,6bR,8aS,10S,12S,12aR,12bS,14bS)-10,12-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate
InChI key:ZIASEWMYFOYGCD-HRSAWRHFSA-N

分子式:C31H50O4
分子量:486.737
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@@]2([H])[C@@]1(C)CC[C@@]1([H])C(C)(C)[C@@H](O)C[C@H](O)[C@]21C)C(=O)OC
SMILES:[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@@]2([H])[C@@]1(C)CC[C@@]1([H])C(C)(C)[C@@H](O)C[C@H](O)[C@]21C)C(=O)OC

Sabialimon P (compound 16) 具抗炎功效，为一种有效的NO释放抑制剂（IC50=18.12 μM）。它可以显著抑制LPS诱导RAW264.7细胞中TNF-α、iNOS、IL-6及NF-κB的产生，并减少COX-2与NF-κB/p65的表达。

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