Name: PROTAC SMARCA2 degrader-17
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT218909564
Cas No:2568276-43-5
常用名:PROTAC SMARCA2 degrader-17
IUPAC:3-(5-{4-[4-(2-{3-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl}pyrimidin-5-yl)piperidin-1-yl]cyclohexyl}-3-methyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)piperidine-2,6-dione
IUPAC:3-(5-{4-[4-(2-{3-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl}pyrimidin-5-yl)piperidin-1-yl]cyclohexyl}-3-methyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)piperidine-2,6-dione
InChI key:RFWLQOKSXYWDAV-UHFFFAOYSA-N

分子式:C44H51N11O4
分子量:797.965
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cn1c2cc(ccc2n(C2CCC(=O)NC2=O)c1=O)C1CCC(CC1)N1CCC(CC1)c1cnc(nc1)N1C2CCC1CN(C2)c1cc(nnc1N)-c1ccccc1O
SMILES:Cn1c2cc(ccc2n(C2CCC(=O)NC2=O)c1=O)C1CCC(CC1)N1CCC(CC1)c1cnc(nc1)N1C2CCC1CN(C2)c1cc(nnc1N)-c1ccccc1O

PROTAC SMARCA2 degrader-17 (compound I-290) 作为针对SMARCA2的高效降解剂，在A549细胞中展示出极佳的活性，DC50值低于100 nM，并在24小时处理后显示出超过90%的最大降解率 (Dmax%)。

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