Name: Homer
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT218929834
Cas No:2737222-94-3
常用名:Homer
IUPAC:N-{4'-[(4-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}butyl)carbamoyl]-4-(4-methylpiperazin-1-yl)-[1,1'-biphenyl]-3-yl}-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
IUPAC:N-{4'-[(4-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}butyl)carbamoyl]-4-(4-methylpiperazin-1-yl)-[1,1'-biphenyl]-3-yl}-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
InChI key:OFNZESNEBSQKSE-BQGOKDIQSA-N

分子式:C52H60F3N9O7S
分子量:1012.16
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1ccc(cc1)C(=O)NCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C
SMILES:CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1ccc(cc1)C(=O)NCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C

Homer是一种针对WDR5的特异性探针。在MV4-11细胞中，该化合物以53 nM的DC50诱导WDR5蛋白的降解。当Homer的浓度达到1 µM时，它能够降低MV4-11细胞中WDR5蛋白的水平，而不会影响其mRNA的表达。

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