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  3. HIT218963664
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HIT218963664
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HIT218963664
  • HIT ID:HIT218963664
  • Cas No:1262770-72-8
  • 常用名:HPI-1 (hydrate)
  • 别名:HPI-1 hydrate
  • IUPAC:2-methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate hydrate
    IUPAC:2-methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate hydrate
  • InChI key:BOASXIAGFOONSK-UHFFFAOYSA-N
  • 分子式:C27H31NO7
  • 分子量:481.545
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:O.COCCOC(=O)C1=C(C)NC2=C(C1c1cccc(O)c1)C(=O)CC(C2)c1ccccc1OC
    SMILES:O.COCCOC(=O)C1=C(C)NC2=C(C1c1cccc(O)c1)C(=O)CC(C2)c1ccccc1OC
  • HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM).1HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor.1HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.1
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    TargetMolSC
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    ¥ 10,600.00
    1

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