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  3. HIT218963751
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HIT218963751
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HIT218963751
  • HIT ID:HIT218963751
  • Cas No:99362-47-7
  • 常用名:3-Hydroxykynurenamine
  • IUPAC:3-amino-1-(2-amino-3-hydroxyphenyl)propan-1-one
    IUPAC:3-amino-1-(2-amino-3-hydroxyphenyl)propan-1-one
  • InChI key:ODOPEICAGBYCFH-UHFFFAOYSA-N
  • 分子式:C9H12N2O2
  • 分子量:180.207
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:NCCC(=O)c1cccc(O)c1N
    SMILES:NCCC(=O)c1cccc(O)c1N
  • 3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1/NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis by decreasing skin thickness, erythema, scaling and fissuring, reducing TNF, IL-1β, IFN-γ, and IL-17 production, and inhibiting generation of effector CD8+ T cells. Similarly, in a mouse model of nephrotoxic nephritis, besides reducing inflammatory cytokines, 3-HKA improves proteinuria and serum urea nitrogen, overall ameliorating immune-mediated glomerulonephritis and renal dysfunction.This compound is unstable in powder form and other related salt forms are recommended.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    3-6月
    纯度
    -
    ¥ 10,600.00
    1

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