CEP-14083 | CAS 856692-39-2

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT218963775
Cas No:856692-39-2
常用名:CEP-14083
IUPAC:1-methyl-3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4(9),5,7,11(15),17,20-octaen-7-yl}-1-phenylurea
IUPAC:1-methyl-3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4(9),5,7,11(15),17,20-octaen-7-yl}-1-phenylurea
InChI key:GOIITZJBPPEODD-UHFFFAOYSA-N

分子式:C31H30N6O2
分子量:518.621
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCn1c2ccc(NC(=O)N(C)c3ccccc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
SMILES:CCCn1c2ccc(NC(=O)N(C)c3ccccc3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12

CEP-14083 is a potent ALK inhibitor that has shown activity in an NPM/ALKÂ–carrying T-cell lymphoma in vitro study. Presumably, this compound binds to the hinge region of the kinase in an ATP-competitive manner. CEP-14083 displays a potent activity against ALK in enzymatic assays (IC50 = 11 nmol/L). Further, CEP-14083 is also able to inhibit the insulin receptor at a concentration within a nanomolar range. In a preclinical assay, CEP-14083 showed that, via NPM/ALK TK inhibition, it could control the expression of molecules that determine T-cell identity and signaling in lymphoma cells. CEP-14083 has shown preclinical activity in both cell lines and animal models harboring ALK alteration.

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~