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  3. HIT218963856
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HIT218963856
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HIT218963856
  • HIT ID:HIT218963856
  • Cas No:2168573-03-1
  • 常用名:SHR0687
  • IUPAC:(2R)-N-[(2R)-6-amino-1-{4-[(methylcarbamoyl)amino]piperidin-1-yl}-1-oxohexan-2-yl]-4-methyl-2-[(2R)-3-phenyl-2-(2-{[(2R)-2-phenylpropyl]amino}acetamido)propanamido]pentanamide
    IUPAC:(2R)-N-[(2R)-6-amino-1-{4-[(methylcarbamoyl)amino]piperidin-1-yl}-1-oxohexan-2-yl]-4-methyl-2-[(2R)-3-phenyl-2-(2-{[(2R)-2-phenylpropyl]amino}acetamido)propanamido]pentanamide
  • InChI key:POEKRJYEMCDIMO-SPYAMJAOSA-N
  • 分子式:C39H60N8O5
  • 分子量:720.96
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CNC(=O)NC1CCN(CC1)C(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)CNC[C@H](C)c1ccccc1
    SMILES:CNC(=O)NC1CCN(CC1)C(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)CNC[C@H](C)c1ccccc1
  • SHR0687 is a Highly Potent KOR Agonist. SHR0687 showed excellent selectivity over other opioid receptors, such as MOR and DOR. In addition, SHR0687 displayed favorable PK profiles across species, as well as robust in vivo efficacy in a<br/><br/>rat carrageenan-induced pain model. Notably, SHR0687 exhibited negligible blood−brain barrier penetration, which was meaningful in minimizing CNS-related side effects.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    10-14周
    纯度
    -
    ¥ 17,200.00
    1

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