Name: RK-582
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT218963861
Cas No:2171388-28-4
常用名:RK-582
IUPAC:6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluoro-1-methyl-1'-{8-methyl-4-oxo-1H,4H,5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-2-yl}-1,2-dihydrospiro[indole-3,4'-piperidin]-2-one
IUPAC:6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluoro-1-methyl-1'-{8-methyl-4-oxo-1H,4H,5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-2-yl}-1,2-dihydrospiro[indole-3,4'-piperidin]-2-one
InChI key:KZUPFZKALLNBBV-CALCHBBNSA-N

分子式:C27H35FN6O3
分子量:510.614
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:C[C@H]1CN(C[C@@H](C)O1)c1cc2N(C)C(=O)C3(CCN(CC3)c3nc(=O)c4CCCN(C)c4[nH]3)c2c(F)c1
SMILES:C[C@H]1CN(C[C@@H](C)O1)c1cc2N(C)C(=O)C3(CCN(CC3)c3nc(=O)c4CCCN(C)c4[nH]3)c2c(F)c1

RK-582 is an orally efficacious spiroindolinone-based tankyrase inhibitor for the treatment of colon cancer. It exhibits a markedly improved robust tumor growth inhibition in a COLO-320DM mouse xenograft model when orally administered.

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