PF-06463922 acetate | CAS 1924207-18-0 | AnyMole

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HIT218963873

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HIT218963873

HIT ID:HIT218963873
Cas No:1924207-18-0
常用名:PF-06463922 acetate
IUPAC:(16R)-19-amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetraazatetracyclo[16.3.1.0^{2,6}.0^{10,15}]docosa-1(21),2,5,10,12,14,18(22),19-octaene-3-carbonitrile; acetic acid
IUPAC:(16R)-19-amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetraazatetracyclo[16.3.1.0^{2,6}.0^{10,15}]docosa-1(21),2,5,10,12,14,18(22),19-octaene-3-carbonitrile; acetic acid
InChI key:BLNAIBLTPYGILH-RFVHGSKJSA-N

分子式:C23H23FN6O4
分子量:466.473
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(O)=O.C[C@H]1Oc2cc(cnc2N)-c2c(CN(C)C(=O)c3ccc(F)cc13)nn(C)c2C#N
SMILES:CC(O)=O.C[C@H]1Oc2cc(cnc2N)-c2c(CN(C)C(=O)c3ccc(F)cc13)nn(C)c2C#N

PF-06463922 acetate is a potent, selective brain-penetrable inhibitor of both anaplastic lymphoma kinase (ALK) and c-ros Oncogene 1 (ROS1) with strong activity against all known ALK and ROS1 mutants identified in patients with crizotinib-resistant disease. PF-06463922 is in clinical trials for the treatment of non–small cell lung cancer (NSCLC).

市场产品/服务共显示2个结果

供应商
TargetMolSC
规格
货期
10-14周
纯度
-
¥ 17,200.00
1
供应商
EnamineBB
规格
货期
4-6周
纯度
-
¥ 6,930.00
1

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