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  3. HIT218963876
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HIT218963876
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HIT218963876
  • HIT ID:HIT218963876
  • Cas No:1825345-52-5
  • 常用名:AZ0108
  • IUPAC:4-({3-[(6S)-3-(1,1-difluoroethyl)-6-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl]phenyl}difluoromethyl)-1,2-dihydrophthalazin-1-one
    IUPAC:4-({3-[(6S)-3-(1,1-difluoroethyl)-6-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl]phenyl}difluoromethyl)-1,2-dihydrophthalazin-1-one
  • InChI key:NWGMIELHSCQGOG-ZDUSSCGKSA-N
  • 分子式:C24H20F4N6O2
  • 分子量:500.458
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:C[C@H]1Cn2c(CN1C(=O)c1cccc(c1)C(F)(F)c1n[nH]c(=O)c3ccccc13)nnc2C(C)(F)F
    SMILES:C[C@H]1Cn2c(CN1C(=O)c1cccc(c1)C(F)(F)c1n[nH]c(=O)c3ccccc13)nnc2C(C)(F)F
  • AZ0108 is an orally bioavailable, potent PARP1,2,6 inhibitor that potently inhibits centrosome clustering and is suitable for in vivo efficacy and tolerability studies. AZ0108 has been utilized as in vitro tools and in vivo probes to investigate the biological consequences of inhibiting centrosome clustering through PARP enzymes. AZ0108 is more selective in its enzyme inhibition profile and effects on cellular pathways and phenotypes. Specifically, AZ0108 inhibits PARPs 1, 2, and 6 with approximately 100-fold selectivity against PARP3 and TNKS1. Consistent with this lack of potencytowards tankyrase, AZ0108 is not active in a DLD-1 Wnt luciferase reporter assay.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    10-14周
    纯度
    -
    ¥ 22,700.00
    1

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