Name: PAT-347
Rating: 5 (10 reviews)

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HIT ID:HIT218963884
Cas No:1689554-51-5
常用名:PAT-347
IUPAC:3-{[6-chloro-1-(2-{1',2'-dihydrospiro[cyclopropane-1,3'-indol]-1'-yl}-2-oxoethyl)-7-fluoro-2-methyl-1H-indol-3-yl]sulfanyl}-2-fluorobenzoic acid
IUPAC:3-{[6-chloro-1-(2-{1',2'-dihydrospiro[cyclopropane-1,3'-indol]-1'-yl}-2-oxoethyl)-7-fluoro-2-methyl-1H-indol-3-yl]sulfanyl}-2-fluorobenzoic acid
InChI key:YFALJJNRFPFPRE-UHFFFAOYSA-N

分子式:C28H21ClF2N2O3S
分子量:538.99
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1c(Sc2cccc(C(O)=O)c2F)c2ccc(Cl)c(F)c2n1CC(=O)N1CC2(CC2)c2ccccc12
SMILES:Cc1c(Sc2cccc(C(O)=O)c2F)c2ccc(Cl)c(F)c2n1CC(=O)N1CC2(CC2)c2ccccc12

PAT-347 is a potent Autotaxin Inhibitor. Autotaxin (ATX) is a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the<br/><br/>bioactive lysophosphatidic acid (LPA) and choline. The ATX-LPA signaling pathway is implicated in cell survival, migration, and proliferation; thus, the inhibition of ATX is a recognized therapeutic target for a number of diseases including fibrotic diseases, cancer, and inflammation, among others.

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