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  3. HIT218963991
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HIT218963991
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HIT218963991
  • HIT ID:HIT218963991
  • Cas No:1064195-48-7
  • 常用名:MF-592
  • IUPAC:1-(2,6-dichlorobenzenesulfonyl)-3-{1-[(4-{4,9-diethoxy-1-oxo-1H,2H,3H-benzo[f]isoindol-2-yl}-3-methylphenyl)methyl]cyclopropyl}urea
    IUPAC:1-(2,6-dichlorobenzenesulfonyl)-3-{1-[(4-{4,9-diethoxy-1-oxo-1H,2H,3H-benzo[f]isoindol-2-yl}-3-methylphenyl)methyl]cyclopropyl}urea
  • InChI key:PSHRSSJDIYJFKV-UHFFFAOYSA-N
  • 分子式:C34H33Cl2N3O6S
  • 分子量:682.61
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)NS(=O)(=O)c2c(Cl)cccc2Cl)cc1C
    SMILES:CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)NS(=O)(=O)c2c(Cl)cccc2Cl)cc1C
  • MF-592 is a potent and selective antagonists of the EP4 receptor. MF-592 demonstrated good functional potency (hEP4 IC50 = 3 nM) and potent inhibition of PGE2 modulated TNFa release in LPS stimulated human whole blood (hWB) (IC50 = 78nM). In addition, it showed an excellent oral pharmacokinetic (PK) profile and in vivo efficacy in a rat chronic adjuvant-induced-arthritis model (ED50 = 0.1 mg/kg/day).. MF-592 has a desirable overall preclinical profile that suggests it is suitable for further development.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    10-14周
    纯度
    -
    ¥ 20,500.00
    1

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