Name: PROTAC SMARCA2 degrader-29
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT219136810
Cas No:2865193-25-3
常用名:PROTAC SMARCA2 degrader-29
IUPAC:(2S,4R)-4-hydroxy-1-[(2R)-2-(3-{4-[3-(2-hydroxyphenyl)thieno[3,2-c]pyridazin-6-yl]-[1,4'-bipiperidin]-1'-yl}-1,2-oxazol-5-yl)-3-methylbutanoyl]-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
IUPAC:(2S,4R)-4-hydroxy-1-[(2R)-2-(3-{4-[3-(2-hydroxyphenyl)thieno[3,2-c]pyridazin-6-yl]-[1,4'-bipiperidin]-1'-yl}-1,2-oxazol-5-yl)-3-methylbutanoyl]-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
InChI key:WXBLQAZKAYEYBG-FYJCVWFUSA-N

分子式:C47H54N8O5S2
分子量:875.12
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(cc1)-c1scnc1C)c1cc(no1)N1CCC(CC1)N1CCC(CC1)c1cc2nnc(cc2s1)-c1ccccc1O
SMILES:CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(cc1)-c1scnc1C)c1cc(no1)N1CCC(CC1)N1CCC(CC1)c1cc2nnc(cc2s1)-c1ccccc1O

PROTAC SMARCA2 degrader-29 (Example 87) 是一种针对SMARCA2(BRM) 的降解剂，其DC50值为10-100 nM (BRM) 而对于BRG1 (别名 SMARCA2) 则超过1 μM。

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~