Name: CPD-10
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT219136833
Cas No:3055471-57-0
常用名:CPD-10
IUPAC:2-{[7-(2-{4-[6-({6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-2-yl}amino)pyridin-3-yl]piperazin-1-yl}acetamido)heptyl]amino}-N-[6-(dimethylamino)pyridazin-3-yl]-6-(methylamino)pyridine-3-carboxamide
IUPAC:2-{[7-(2-{4-[6-({6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-2-yl}amino)pyridin-3-yl]piperazin-1-yl}acetamido)heptyl]amino}-N-[6-(dimethylamino)pyridazin-3-yl]-6-(methylamino)pyridine-3-carboxamide
InChI key:WFFZVPVWIAASIW-UHFFFAOYSA-N

分子式:C46H61N15O4
分子量:888.095
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CNc1ccc(C(=O)Nc2ccc(nn2)N(C)C)c(NCCCCCCCNC(=O)CN2CCN(CC2)c2ccc(Nc3ncc4c(C)c(C(C)=O)c(=O)n(C5CCCC5)c4n3)nc2)n1
SMILES:CNc1ccc(C(=O)Nc2ccc(nn2)N(C)C)c(NCCCCCCCNC(=O)CN2CCN(CC2)c2ccc(Nc3ncc4c(C)c(C(C)=O)c(=O)n(C5CCCC5)c4n3)nc2)n1

CPD-10是一种针对CCND1和CDK4的高效异双功能PROTAC降解剂，能有效抑制细胞增殖并诱导细胞凋亡(apoptosis)。此外，CPD-10能够剂量依赖性地降低细胞周期蛋白D1、细胞周期蛋白D3、CDK4、P-Rb(5807/811)的蛋白水平。

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