Name: EB1002
Rating: 5 (10 reviews)

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HIT ID:HIT219136868
Cas No:2770688-48-5
常用名:EB1002
IUPAC:17-{[(1S)-3-[(2-{2-[({2-[2-({[(1S)-1-{[(1S)-5-amino-1-{[(1S)-1-{[(1S)-1-[({[(1S)-1-{[(1S)-1-carbamoyl-3-methoxypropyl]carbamoyl}-3-methylbutyl](methyl)carbamoyl}methyl)carbamoyl]-2-methylpropyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}pentyl]carbamoyl}-2-carboxyethyl]carbamoyl}methoxy)ethoxy]ethyl}carbamoyl)methoxy]ethoxy}ethyl)carbamoyl]-1-carboxypropyl]carbamoyl}heptadecanoic acid
IUPAC:17-{[(1S)-3-[(2-{2-[({2-[2-({[(1S)-1-{[(1S)-5-amino-1-{[(1S)-1-{[(1S)-1-[({[(1S)-1-{[(1S)-1-carbamoyl-3-methoxypropyl]carbamoyl}-3-methylbutyl](methyl)carbamoyl}methyl)carbamoyl]-2-methylpropyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}pentyl]carbamoyl}-2-carboxyethyl]carbamoyl}methoxy)ethoxy]ethyl}carbamoyl)methoxy]ethoxy}ethyl)carbamoyl]-1-carboxypropyl]carbamoyl}heptadecanoic acid
InChI key:SMIDDQXCMJFZEC-PPTFQZPPSA-N

分子式:C73H124N12O23
分子量:1537.856
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COCC[C@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)C(C)C)C(N)=O
SMILES:COCC[C@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)C(C)C)C(N)=O

EB1002 是一种选择性NK2R激动剂，能够显著增加肥胖小鼠中线粒体生物合成相关基因（如PGC-1α）的表达，从而通过增强线粒体活动促进能量消耗。此外，它还提高了小鼠的胰岛素敏感性，并改善了糖脂代谢。因此，EB1002 有望用于针对肥胖和2型糖尿病的研究。

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