Name: T-22
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT219136943
Cas No:147658-54-6
常用名:T-22
别名:[Tyr5,12,Lys7]-Polyphemusin II
IUPAC:(2S)-2-[(2S)-2-amino-5-carbamimidamidopentanamido]-5-carbamimidamido-N-[(1S)-2-(1H-indol-3-yl)-1-{[(1R,4S,7S,10S,13R,18R,21S,24S,27S,30R,33S,39S,42S)-4,21,39-tris(4-aminobutyl)-18-{[(1S)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}-7,24-bis(3-carbamimidamidopropyl)-10,27,33,42-tetrakis[(4-hydroxyphenyl)methyl]-3,6,9,12,20,23,26,29,32,35,38,41,44-tridecaoxo-15,16,46,47-tetrathia-2,5,8,11,19,22,25,28,31,34,37,40,43-tridecaazabicyclo[28.14.4]octatetracontan-13-yl]carbamoyl}ethyl]pentanamide
IUPAC:(2S)-2-[(2S)-2-amino-5-carbamimidamidopentanamido]-5-carbamimidamido-N-[(1S)-2-(1H-indol-3-yl)-1-{[(1R,4S,7S,10S,13R,18R,21S,24S,27S,30R,33S,39S,42S)-4,21,39-tris(4-aminobutyl)-18-{[(1S)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}-7,24-bis(3-carbamimidamidopropyl)-10,27,33,42-tetrakis[(4-hydroxyphenyl)methyl]-3,6,9,12,20,23,26,29,32,35,38,41,44-tridecaoxo-15,16,46,47-tetrathia-2,5,8,11,19,22,25,28,31,34,37,40,43-tridecaazabicyclo[28.14.4]octatetracontan-13-yl]carbamoyl}ethyl]pentanamide
InChI key:MJULKHZUJYASFR-FQPMSUGVSA-N

分子式:C109H164N38O22S4
分子量:2487
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@]12CSSC[C@]([H])(NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc3ccc(O)cc3)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N2)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
SMILES:[H][C@]12CSSC[C@]([H])(NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc3ccc(O)cc3)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N2)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

T-22 ([Tyr5,12,Lys7]-Polyphemusin II) 作为一种抗HIV合成肽，具有很高的活性，其EC50为0.008 μg/mL，而CC50则为54 μg/mL。此外，T-22在提高番茄植株的株高、光合作用效率、总叶绿素含量及植株气体交换能力等方面显示出显著效果，且能有效抵抗CMV。

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