Name: DTS-108
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT219200994
Cas No:951792-83-9
常用名:DTS-108
IUPAC:(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-{2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2R)-2-amino-3-[(2,5-dioxo-1-{[(1r,4r)-4-({[(1r,4r)-4-({[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl]oxy}carbonyl)cyclohexyl]methyl}carbamoyl)cyclohexyl]methyl}pyrrolidin-3-yl)sulfanyl]propanamido]-3-methylbutanamido]hexanamido]-5-carbamimidamidopentanamido]acetamido}-4-methylpentanamido]hexanamido]-4-methylpentanamido]-5-carbamimidamidopentanamido]-3-(1H-imidazol-5-yl)propanamido]-3-methylbutanamido]-5-carbamimidamidopentanoyl]pyrrolidin-2-yl]formamido}-5-carbamimidamidopentanamido]-3-methylbutanamido]-3-hydroxybutanamido]-5-carbamimidamidopentanamido]-4-(methylsulfanyl)butanamido]-3-carboxypropanamido]-3-methylbutanoic acid
IUPAC:(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-{2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2R)-2-amino-3-[(2,5-dioxo-1-{[(1r,4r)-4-({[(1r,4r)-4-({[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl]oxy}carbonyl)cyclohexyl]methyl}carbamoyl)cyclohexyl]methyl}pyrrolidin-3-yl)sulfanyl]propanamido]-3-methylbutanamido]hexanamido]-5-carbamimidamidopentanamido]acetamido}-4-methylpentanamido]hexanamido]-4-methylpentanamido]-5-carbamimidamidopentanamido]-3-(1H-imidazol-5-yl)propanamido]-3-methylbutanamido]-5-carbamimidamidopentanoyl]pyrrolidin-2-yl]formamido}-5-carbamimidamidopentanamido]-3-methylbutanamido]-3-hydroxybutanamido]-5-carbamimidamidopentanamido]-4-(methylsulfanyl)butanamido]-3-carboxypropanamido]-3-methylbutanoic acid
InChI key:FWGGCDGFVSQQOB-XFIPQAIFSA-N

分子式:C145H233N43O33S2
分子量:3170.85
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OC(=O)[C@H]3CC[C@H](CNC(=O)[C@H]4CC[C@H](CN5C(=O)CC(SC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc6cnc[nH]6)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N6CCC[C@H]6C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(O)=O)C5=O)CC4)CC3)cc12
SMILES:CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OC(=O)[C@H]3CC[C@H](CNC(=O)[C@H]4CC[C@H](CN5C(=O)CC(SC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc6cnc[nH]6)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N6CCC[C@H]6C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(O)=O)C5=O)CC4)CC3)cc12

DTS-108 是 SN38 (一种拓扑异构酶 I抑制剂) 的前药。作为一种偶联物，DTS-108 通过酯酶敏感的交联剂将 SN38 与人类寡肽相连接。DTS-108 展现出对结直肠癌、肺癌和乳腺癌的抗癌活性。

市场产品/服务共显示1个结果

供应商
TargetMolSC
规格
货期
纯度
-
待询
1

寻找合适的化合物库

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~