BTX6654 | BTX-6654 | BTX 6654 | AnyMole

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HIT219201239

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HIT219201239

HIT ID:HIT219201239
Cas No:
常用名:BTX6654
别名:BTX-6654, BTX 6654
IUPAC:3-{6-fluoro-5-[1-(3-{4-[4-(1-methyl-4-{[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino}phthalazin-6-yl)piperazine-1-carbonyl]piperidin-1-yl}-3-oxopropyl)piperidin-4-yl]-1-oxo-2,3-dihydro-1H-isoindol-2-yl}piperidine-2,6-dione
IUPAC:3-{6-fluoro-5-[1-(3-{4-[4-(1-methyl-4-{[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino}phthalazin-6-yl)piperazine-1-carbonyl]piperidin-1-yl}-3-oxopropyl)piperidin-4-yl]-1-oxo-2,3-dihydro-1H-isoindol-2-yl}piperidine-2,6-dione
InChI key:OZZGLWHPVOGDLB-LHMLQLIOSA-N

分子式:C50H57F4N9O5
分子量:940.058
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(CC1)C(=O)C1CCN(CC1)C(=O)CCN1CCC(CC1)c1cc2CN(C3CCC(=O)NC3=O)C(=O)c2cc1F)c1cccc(c1C)C(F)(F)F
SMILES:C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(CC1)C(=O)C1CCN(CC1)C(=O)CCN1CCC(CC1)c1cc2CN(C3CCC(=O)NC3=O)C(=O)c2cc1F)c1cccc(c1C)C(F)(F)F

BTX-6654是一种基于cereblon的SOS1 PROTAC双功能降解剂。该化合物通过减少下游信号标志物pERK和pS6的表达，对携带多种KRAS突变的细胞表现出抗增殖活性。

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