Name: Cbl-b-IN-6
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT219234678
Cas No:2815221-33-9
常用名:Cbl-b-IN-6
IUPAC:2-(3-{3,3-difluoro-1-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]cyclobutyl}phenyl)-6-[(1S)-1-[(1-methylcyclobutyl)amino]ethyl]-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one
IUPAC:2-(3-{3,3-difluoro-1-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]cyclobutyl}phenyl)-6-[(1S)-1-[(1-methylcyclobutyl)amino]ethyl]-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one
InChI key:WPMBSZUSDZRKJO-SFHVURJKSA-N

分子式:C30H32F5N5O
分子量:573.612
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:C[C@H](NC1(C)CCC1)c1cc2C(=O)N(Cc2c(c1)C(F)(F)F)c1cccc(c1)C1(Cc2nncn2C)CC(F)(F)C1
SMILES:C[C@H](NC1(C)CCC1)c1cc2C(=O)N(Cc2c(c1)C(F)(F)F)c1cccc(c1)C1(Cc2nncn2C)CC(F)(F)C1

Cbl-b-IN-6 (Compound 246)，作为casitas B系淋巴瘤（Cbl-b）和c-Cbl的抑制剂，其IC50值分别为5.8 nM和4.4 nM。

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