Name: PROTAC HDAC6 degrader 3
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT219250756
Cas No:
常用名:PROTAC HDAC6 degrader 3
IUPAC:(2S,4R)-1-[(2S)-2-{2-[2-(2-{[({3-[({5-[5-(difluoromethyl)-1,3,4-oxadiazol-2-yl]pyrimidin-2-yl}amino)methyl]phenyl}methyl)carbamoyl]methoxy}ethoxy)ethoxy]acetamido}-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
IUPAC:(2S,4R)-1-[(2S)-2-{2-[2-(2-{[({3-[({5-[5-(difluoromethyl)-1,3,4-oxadiazol-2-yl]pyrimidin-2-yl}amino)methyl]phenyl}methyl)carbamoyl]methoxy}ethoxy)ethoxy]acetamido}-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
InChI key:FPHZTEVAFYKQKC-ZTHQHTSKSA-N

分子式:C46H56F2N10O9S
分子量:963.07
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)COCCOCCOCC(=O)NCc1cccc(CNc2ncc(cn2)-c2nnc(o2)C(F)F)c1)C(C)(C)C)c1ccc(cc1)-c1scnc1C
SMILES:C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)COCCOCCOCC(=O)NCc1cccc(CNc2ncc(cn2)-c2nnc(o2)C(F)F)c1)C(C)(C)C)c1ccc(cc1)-c1scnc1C

PROTACHDAC6 degrader 3 (Compound 4) 为一种选择性抑制剂和降解剂，针对HDAC6的IC50为686 nM，DC50为171 nM。该化合物促进α-微管蛋白 (α-tubulin) 的乙酰化。(Pink: ligand for target protein; Blue: ligand for E3ligaseVHL)

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~