Name: ABBV-969 Payload
Rating: 5 (10 reviews)

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HIT ID:HIT219422878
Cas No:2857037-70-6
常用名:ABBV-969 Payload
别名:Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT
别名:Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT
IUPAC:(2S)-2-(2-bromoacetamido)-N-[(1S)-1-({3-[(5S)-5-ethyl-5-hydroxy-6,10-dioxo-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.0^{2,11}.0^{4,9}.0^{15,23}.0^{17,21}]tetracosa-1(24),2,4(9),13,15,17(21),22-heptaen-14-yl]bicyclo[1.1.1]pentan-1-yl}carbamoyl)ethyl]-3-methylbutanamide
IUPAC:(2S)-2-(2-bromoacetamido)-N-[(1S)-1-({3-[(5S)-5-ethyl-5-hydroxy-6,10-dioxo-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.0^{2,11}.0^{4,9}.0^{15,23}.0^{17,21}]tetracosa-1(24),2,4(9),13,15,17(21),22-heptaen-14-yl]bicyclo[1.1.1]pentan-1-yl}carbamoyl)ethyl]-3-methylbutanamide
InChI key:RCIVGZZPQGHOGN-JLVKPTLHSA-N

分子式:C36H38BrN5O9
分子量:764.63
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc5OCOc5cc4c(c3Cn1c2=O)C12CC(C1)(C2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)CBr)C(C)C
SMILES:CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc5OCOc5cc4c(c3Cn1c2=O)C12CC(C1)(C2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)CBr)C(C)C

ABBV-969 Payload (Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT) 是一种药物-连接子偶联物，用于抗体药物偶联物（ADCs）合成。该载荷含有拓扑异构酶 I 抑制剂分子及化学连接子，可与抗 c-Met 抗体偶联，从而生成具有靶向抗癌活性的 ABBV-969 ADCs。

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