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  3. HIT219431668
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HIT219431668
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HIT219431668
  • HIT ID:HIT219431668
  • Cas No:64881-21-6
  • 常用名:Caricotamide
  • IUPAC:1-(carbamoylmethyl)-1,4-dihydropyridine-3-carboxamide
    IUPAC:1-(carbamoylmethyl)-1,4-dihydropyridine-3-carboxamide
  • InChI key:WEJRSYKFMCUCRQ-UHFFFAOYSA-N
  • 分子式:C8H11N3O2
  • 分子量:181.195
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:NC(=O)CN1C=CCC(=C1)C(N)=O
    SMILES:NC(=O)CN1C=CCC(=C1)C(N)=O
  • Caricotamide is a synthetic co-substrate that activates the human endogenous enzyme NRH:quinone oxidoreductase 2 (NQO2) with potential chemoadjuvant activity. When caricotamide is administered simultaneously with the prodrug tretazicar, NQO2 converts tretazicar to the bifunctional alkylating agent dinitrobenzamide, which is capable of forming a high degree of DNA interstrand cross-links, resulting in the inhibition of DNA replication and the induction of apoptosis. NQO2 has been found to be over-expressed in cancers such as hepatocellular carcinoma (HCC), colorectal and ovarian cancers.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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