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  3. HIT219437862
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HIT219437862
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HIT219437862
  • HIT ID:HIT219437862
  • Cas No:1345810-21-0
  • 常用名:CB-1158-analog
  • IUPAC:2-amino-2-{1-[(2,4-dichlorophenyl)methyl]piperidin-4-yl}-6-(dihydroxyboranyl)hexanoic acid
    IUPAC:2-amino-2-{1-[(2,4-dichlorophenyl)methyl]piperidin-4-yl}-6-(dihydroxyboranyl)hexanoic acid
  • InChI key:ISYBHIALKUAHGV-UHFFFAOYSA-N
  • 分子式:C18H27BCl2N2O4
  • 分子量:417.13
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:NC(CCCCB(O)O)(C1CCN(Cc2ccc(Cl)cc2Cl)CC1)C(O)=O
    SMILES:NC(CCCCB(O)O)(C1CCN(Cc2ccc(Cl)cc2Cl)CC1)C(O)=O
  • CB-1158-analog, also known as Numidargistat-analog and INCB01158-analog, is a potent and orally active arginase inhibitor with IC50=89 nM) . CB-1158 blocked myeloid cell-mediated suppression of T cell proliferation in vitro and reduced tumor growth in multiple mouse models of cancer, as a single agent and in combination with checkpoint blockade, adoptive T cell therapy, adoptive NK cell therapy, and the chemotherapy agent gemcitabine. CB-1158 increased tumor-infiltrating CD8+ T cells and NK cells, inflammatory cytokines, and expression of interferon-inducible genes. CB-1158 may be potentially useful in renal cell cancer, breast cancer, non-small cell lung cancer, acute myeloid leukemia, and other tumor types where arginase-secreting MDSCs are known to play an immunosuppressive role. (see ADDITIONAL INFORMATION in this web page for CB-1158 structure confusion).
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 11,700.00
    1

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