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  3. HIT219438128
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HIT219438128
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HIT219438128
  • HIT ID:HIT219438128
  • Cas No:459814-89-2
  • 常用名:AZD-1236
  • IUPAC:(5S)-5-[({4-[(5-chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]-5-methylimidazolidine-2,4-dione
    IUPAC:(5S)-5-[({4-[(5-chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]-5-methylimidazolidine-2,4-dione
  • InChI key:SFJFBTPHDHUUPU-OAHLLOKOSA-N
  • 分子式:C15H19ClN4O5S
  • 分子量:402.85
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:C[C@]1(CS(=O)(=O)N2CCC(CC2)Oc2ccc(Cl)cn2)NC(=O)NC1=O
    SMILES:C[C@]1(CS(=O)(=O)N2CCC(CC2)Oc2ccc(Cl)cn2)NC(=O)NC1=O
  • AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12 (IC50 = 4.5 and 6.1nM, respectively), with >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other members of the enzyme family. AZD1236 activity is approximately 20 to 50-fold lower at the rat, mouse, and guinea pig orthologues. In acute models of lung injury, AZD1236 inhibited the haemorrhage and inflammation induced by instillation of human MMP-12 into rat lungs by ~80% at 0.81mg/kg, and also abolished macrophage infiltration into BAL fluid induced by tobacco smoke inhalation in the mouse.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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