Name: CK0106023
Rating: 5 (10 reviews)

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HIT ID:HIT219441661
Cas No:336115-72-1
常用名:CK0106023
IUPAC:N-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)propyl]-4-bromo-N-[3-(dimethylamino)propyl]benzamide
IUPAC:N-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)propyl]-4-bromo-N-[3-(dimethylamino)propyl]benzamide
InChI key:PZVLDHUUSWUATQ-UHFFFAOYSA-N

分子式:C30H32BrClN4O2
分子量:595.97
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCC(N(CCCN(C)C)C(=O)c1ccc(Br)cc1)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1
SMILES:CCC(N(CCCN(C)C)C(=O)c1ccc(Br)cc1)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1

CK0106023 was specific inhibitor of KSP. In tumor-bearing mice, CK0106023 exhibited antitumor activity comparable to or exceeding that of paclitaxel and caused the formation of monopolar mitotic figures identical to those produced in cultured cells. KSP was most abundant in proliferating human tissues and was absent from cultured postmitotic neurons.

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