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  3. HIT219452658
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HIT219452658
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HIT219452658
  • HIT ID:HIT219452658
  • Cas No:150034-24-5;149838-21-1
  • 常用名:PD-85639
  • IUPAC:N-[3-(2,6-dimethylpiperidin-1-yl)propyl]-2,2-diphenylacetamide
    IUPAC:N-[3-(2,6-dimethylpiperidin-1-yl)propyl]-2,2-diphenylacetamide
  • InChI key:BPZBEIHSHWNWTE-UHFFFAOYSA-N
  • 分子式:C24H32N2O
  • 分子量:364.533
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CC1CCCC(C)N1CCCNC(=O)C(c1ccccc1)c1ccccc1
    SMILES:CC1CCCC(C)N1CCCNC(=O)C(c1ccccc1)c1ccccc1
  • PD-85639 is a voltage-gated sodium (Na+) channel blocker (75% in 10 min & >95% in 25 min blockage of Na+ current by 25 μM PD85,639; whole-cell patch clamp using primary rat brain neurons) that is shown to target rat brain Nav1.2 with simultaneous high- and low-affinity modes of binding (EC50 = 56 nM/40% & 20 μM/60% at pH 9.0, 5 nM/28% & 3 μM/72% at pH 7.4, against 2 nM [3H]-PD85,639 for binding rat brain synaptosomes; EC50 = 17 nM/39% & 10 μM/61% using at pH 9.0 using rat brain synaptosome membranes) and a fast kinetic (t1/2 = 1.2 at 4°C, <0.5 min at 25°C), competitive against the local anesthetic Na+ channel blockers tetracaine, bupivacaine, and mepivacaine, as well as Na+ channel activators veratridine and batrachotoxin (K1 = 0.26 μM against 5 nM [3H]-BTX for binding rat neocrotical membranes).
市场产品/服务共显示2个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1
  • 供应商
    EnamineBB
    规格
    货期
    4-6周
    纯度
    -
    ¥ 5,518.00
    1

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