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HIT219452661
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HIT219452661
  • HIT ID:HIT219452661
  • Cas No:1354712-92-7
  • 常用名:PF05020182
  • IUPAC:N-[4,6-dimethoxy-2-(4-methoxypiperidin-1-yl)pyrimidin-5-yl]-3,3-dimethylbutanamide
    IUPAC:N-[4,6-dimethoxy-2-(4-methoxypiperidin-1-yl)pyrimidin-5-yl]-3,3-dimethylbutanamide
  • InChI key:XHJMCIALHJMEBB-UHFFFAOYSA-N
  • 分子式:C18H30N4O4
  • 分子量:366.462
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:COC1CCN(CC1)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1
    SMILES:COC1CCN(CC1)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1
  • PF05020182 is novel potent and selective Kv7.2/4 potassium channel opener. PF-05020182 (2) significantly inhibits convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochemical properties, in vitro and in vivo activities of PF-05020182 support further development as an adjunctive treatment of refractory epilepsy. Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous electrical activity during epileptic seizures.
市场产品/服务共显示3个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1
  • 供应商
    EnamineBB
    规格
    货期
    4-6周
    纯度
    -
    ¥ 17,398.00
    1
  • 供应商
    EnamineSC
    规格
    货期
    4-6周
    纯度
    -
    ¥ 1,177.00
    1

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