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  3. HIT219460314
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HIT219460314
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HIT219460314
  • HIT ID:HIT219460314
  • Cas No:872141-23-6
  • 常用名:WAY-255348
  • IUPAC:5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile
    IUPAC:5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile
  • InChI key:KIOOLNRTWPFVHX-UHFFFAOYSA-N
  • 分子式:C16H14FN3O
  • 分子量:283.306
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Cn1c(ccc1-c1cc2c(NC(=O)C2(C)C)c(F)c1)C#N
    SMILES:Cn1c(ccc1-c1cc2c(NC(=O)C2(C)C)c(F)c1)C#N
  • WAY-255348 is a potent nonsteroidal progesterone receptor (PR) antagonist. WAY-255348 inhibits the activity of progesterone. WAY-255348 achieves antagonist activity by binding to and subsequently preventing progesterone-induced nuclear accumulation, phosphorylation and promoter interactions of the PR. WAY-255348 bound PR conformation was similar to that of a progesterone agonist-bound PR and distinct from steroidal antagonist-bound PR conformations. WAY-255348 inhibits PR action through a novel molecular mechanism that is distinct from previously studied PR modulators and may be a useful tool to further understanding of PR signaling pathways.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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