Name: TTC-352
Rating: 5 (10 reviews)

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HIT ID:HIT219461640
Cas No:1607819-68-0
常用名:TTC-352
IUPAC:3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)-1-benzothiophen-6-ol
IUPAC:3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)-1-benzothiophen-6-ol
InChI key:UDBMVVLTKJMPCJ-UHFFFAOYSA-N

分子式:C20H13FO3S
分子量:352.38
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Oc1ccc(Oc2sc3cc(O)ccc3c2-c2ccc(F)cc2)cc1
SMILES:Oc1ccc(Oc2sc3cc(O)ccc3c2-c2ccc(F)cc2)cc1

TTC-352 is an orally bioavailable selective human estrogen receptor alpha (ERalpha; ESR1; ERa) partial agonist (ShERPA), with potential antineoplastic activity. Upon administration, TTC-352 mimics the naturally-occurring 17beta-estradiol (E2) and targets and binds to ERa located in the nucleus. This causes translocation of ERa to extranuclear sites. Nuclear export of ERa prevents normal ER-mediated signaling and inhibits proliferation of ER-positive tumor cells.

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