Name: Oxanosine
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT219465093
Cas No:80394-72-5
常用名:Oxanosine
IUPAC:5-amino-3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,7H-imidazo[4,5-d][1,3]oxazin-7-one
IUPAC:5-amino-3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,7H-imidazo[4,5-d][1,3]oxazin-7-one
InChI key:PWVUOVPUCZNICU-ZIYNGMLESA-N

分子式:C10H12N4O6
分子量:284.228
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Nc1nc2n(cnc2c(=O)o1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
SMILES:Nc1nc2n(cnc2c(=O)o1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

Oxanosine is an analog of guanosine that has been found in S. capreolus and has diverse biological activities, including antibacterial, antiviral, and anticancer properties. It is active against a variety of bacteria, including S. flexneri, P. mirabilis, and E. coli (MICs = 6.25, 12.5, 25 µg/ml, respectively, on peptone, but not nutrient, agar). Oxanosine inhibits replication of the HIV-1 strain IIIb in infected CEM and U937, but not H9, cells (EC50s = 7, 27, and >500 µg/ml, respectively). It also inhibits the growth of HeLa human cervical cancer cells (IC50 = 32 µg/ml) and reduces tumor growth in a murine L1210 lymphocytic leukemia model.

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