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  3. HIT219468188
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HIT219468188
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HIT219468188
  • HIT ID:HIT219468188
  • Cas No:183499-56-1
  • 常用名:L-778123 Dihydrochloride
  • IUPAC:4-[(5-{[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl}-1H-imidazol-1-yl)methyl]benzonitrile dihydrochloride
    IUPAC:4-[(5-{[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl}-1H-imidazol-1-yl)methyl]benzonitrile dihydrochloride
  • InChI key:XNGJWEBJQJQXQR-UHFFFAOYSA-N
  • 分子式:C22H22Cl3N5O
  • 分子量:478.8
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Cl.Cl.Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1=O
    SMILES:Cl.Cl.Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1=O
  • L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed.
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  • 供应商
    TargetMolSC
    规格
    货期
    1-2周
    纯度
    -
    ¥ 10,600.00
    1

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