Name: 3A-MPLA
Rating: 5 (10 reviews)

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类似物检索

HIT ID:HIT219469074
Cas No:1699735-80-2
常用名:3A-MPLA
IUPAC:ammonium (2R,3S,4R,5R,6R)-4-hydroxy-2-(hydroxymethyl)-5-[(3R)-3-(tetradecanoyloxy)tetradecanamido]-6-{[(2R,3S,4R,5R,6S)-3,4,6-trihydroxy-5-[(3R)-3-hydroxytetradecanamido]oxan-2-yl]methoxy}oxan-3-yl hydrogen phosphate
IUPAC:ammonium (2R,3S,4R,5R,6R)-4-hydroxy-2-(hydroxymethyl)-5-[(3R)-3-(tetradecanoyloxy)tetradecanamido]-6-{[(2R,3S,4R,5R,6S)-3,4,6-trihydroxy-5-[(3R)-3-hydroxytetradecanamido]oxan-2-yl]methoxy}oxan-3-yl hydrogen phosphate
InChI key:WBMOMCHVNLUEBA-MWYCKLIASA-N

分子式:C54H106N3O17P
分子量:1100.42
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[NH4+].CCCCCCCCCCCCCC(=O)O[C@H](CCCCCCCCCCC)CC(=O)N[C@@H]1[C@@H](O)[C@H](OP(O)([O-])=O)[C@@H](CO)O[C@H]1OC[C@H]1O[C@H](O)[C@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](O)[C@@H]1O
SMILES:[NH4+].CCCCCCCCCCCCCC(=O)O[C@H](CCCCCCCCCCC)CC(=O)N[C@@H]1[C@@H](O)[C@H](OP(O)([O-])=O)[C@@H](CO)O[C@H]1OC[C@H]1O[C@H](O)[C@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](O)[C@@H]1O

Monophosphoryl lipid A (MPLA) is a natural agonist for the toll-like receptor-4 (TLR4). It is useful as an adjuvant in immunization. MPLA is a safe prophylactic agent and has immunotherapeutic applications. It induces tumor necrosis factor and interleukin (IL)-1β, however not as efficient as lipopolysaccharide (LPS). MPLA improves immune response during bacterial sepsis infection.

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