Name: AM-211 sodium
Rating: 5 (10 reviews)

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HIT ID:HIT219469117
Cas No:1263077-74-2
常用名:AM-211 sodium
IUPAC:sodium 2-(2'-{[(benzylcarbamoyl)(ethyl)amino]methyl}-6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetate
IUPAC:sodium 2-(2'-{[(benzylcarbamoyl)(ethyl)amino]methyl}-6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetate
InChI key:FMIRMLZTNYEOKX-UHFFFAOYSA-M

分子式:C27H26F3N2NaO4
分子量:522.5
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[Na+].CCN(Cc1cc(ccc1-c1cc(CC([O-])=O)ccc1OC)C(F)(F)F)C(=O)NCc1ccccc1
SMILES:[Na+].CCN(Cc1cc(ccc1-c1cc(CC([O-])=O)ccc1OC)C(F)(F)F)C(=O)NCc1ccccc1

AM-211 sodium is a novel and potent antagonist of the prostaglandin D2 receptor type 2. AM-211 is active in animal models of allergic inflammation. AM211 has high affinity for human, mouse, rat, and guinea pig DP2 and it shows selectivity over other prostanoid receptors and enzymes. AM211 exhibits good oral bioavailability in rats and dogs and dose-dependently inhibits 13,14-dihydro-15-keto-PGD(2)-induced leukocytosis in a guinea pig pharmacodynamic assay.

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