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  3. HIT219469119
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HIT219469119
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HIT219469119
  • HIT ID:HIT219469119
  • Cas No:1037837-27-6
  • 常用名:ARN 14494
  • IUPAC:N-methyl-1-[1-(2-{octahydrocyclopenta[c]pyrrol-2-yl}-2-oxoethyl)piperidin-4-yl]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide
    IUPAC:N-methyl-1-[1-(2-{octahydrocyclopenta[c]pyrrol-2-yl}-2-oxoethyl)piperidin-4-yl]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide
  • InChI key:TYZOOEYUTZDYPB-UHFFFAOYSA-N
  • 分子式:C24H32N4O3
  • 分子量:424.545
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CNC(=O)c1ccc2N(C3CCN(CC(=O)N4CC5CCCC5C4)CC3)C(=O)Cc2c1
    SMILES:CNC(=O)c1ccc2N(C3CCN(CC(=O)N4CC5CCCC5C4)CC3)C(=O)Cc2c1
  • ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 11,700.00
    1

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