Name: HR-19011
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT219469199
Cas No:2851820-52-3
常用名:HR-19011
别名:HR19011, EIF2α activator 1
IUPAC:3-[(3,4-dioxo-2-{[(1r,4r)-4-[4-(trifluoromethyl)phenoxy]cyclohexyl]amino}cyclobut-1-en-1-yl)amino]-5-(trifluoromethyl)benzonitrile
IUPAC:3-[(3,4-dioxo-2-{[(1r,4r)-4-[4-(trifluoromethyl)phenoxy]cyclohexyl]amino}cyclobut-1-en-1-yl)amino]-5-(trifluoromethyl)benzonitrile
InChI key:PYDUAMACJGQTQN-RUCARUNLSA-N

分子式:C25H19F6N3O3
分子量:523.435
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:FC(F)(F)c1ccc(O[C@H]2CC[C@@H](CC2)Nc2c(Nc3cc(cc(c3)C(F)(F)F)C#N)c(=O)c2=O)cc1
SMILES:FC(F)(F)c1ccc(O[C@H]2CC[C@@H](CC2)Nc2c(Nc3cc(cc(c3)C(F)(F)F)C#N)c(=O)c2=O)cc1

HR-19011 (Compound 40) is an inducer of eIF2α phosphorylation that increases expression levels of downstream proteins ATF and CHOP, exhibiting micromolar-level antiproliferative activity against K562 and PBMC cells.

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