Name: Paluratide
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT219506023
Cas No:2676177-63-0
常用名:Paluratide
别名:帕鲁拉肽, LUNA18, LUNA 18
IUPAC:(3'S,9'S,12'S,17'S,20'S,23'S,27'S,30'S,36'S)-20'-[(2S)-butan-2-yl]-30'-cyclopentyl-3'-{2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl}-10'-ethyl-N,N,7',17',18',24',28',31'-octamethyl-9'-[(4-methylphenyl)methyl]-23'-(2-methylpropyl)-2',5',8',11',16',19',22',25',29',32',35'-undecaoxo-1',4',7',10',15',18',21',24',28',31',34'-undecaazaspiro[cyclopentane-1,33'-tricyclo[34.3.0.0^{12,15}]nonatriacontane]-27'-carboxamide
IUPAC:(3'S,9'S,12'S,17'S,20'S,23'S,27'S,30'S,36'S)-20'-[(2S)-butan-2-yl]-30'-cyclopentyl-3'-{2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl}-10'-ethyl-N,N,7',17',18',24',28',31'-octamethyl-9'-[(4-methylphenyl)methyl]-23'-(2-methylpropyl)-2',5',8',11',16',19',22',25',29',32',35'-undecaoxo-1',4',7',10',15',18',21',24',28',31',34'-undecaazaspiro[cyclopentane-1,33'-tricyclo[34.3.0.0^{12,15}]nonatriacontane]-27'-carboxamide
InChI key:ZQVKVYRBKAEFPD-DEBTURSASA-N

分子式:C73H105F5N12O12
分子量:1437.707
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12CCN1C(=O)[C@H](C)N(C)C(=O)[C@@]([H])(NC(=O)[C@H](CC(C)C)N(C)C(=O)C[C@H](N(C)C(=O)[C@H](C1CCCC1)N(C)C(=O)C1(CCCC1)NC(=O)[C@]1([H])CCCN1C(=O)[C@H](CCc1cc(F)c(c(F)c1)C(F)(F)F)NC(=O)CN(C)C(=O)[C@H](Cc1ccc(C)cc1)N(CC)C2=O)C(=O)N(C)C)[C@@H](C)CC
SMILES:[H][C@@]12CCN1C(=O)[C@H](C)N(C)C(=O)[C@@]([H])(NC(=O)[C@H](CC(C)C)N(C)C(=O)C[C@H](N(C)C(=O)[C@H](C1CCCC1)N(C)C(=O)C1(CCCC1)NC(=O)[C@]1([H])CCCN1C(=O)[C@H](CCc1cc(F)c(c(F)c1)C(F)(F)F)NC(=O)CN(C)C(=O)[C@H](Cc1ccc(C)cc1)N(CC)C2=O)C(=O)N(C)C)[C@@H](C)CC

Paluratide(LUNA18,帕鲁拉肽)是一种可逆的环肽KRAS抑制剂，具有可口服和细胞渗透性的优点，用于治疗kras突变型癌症，通过磷酸化 ERK 和 AKT抑制癌细胞增殖，还能够抑制 RAS 与鸟嘌呤核苷酸交换因子 (GEFs) 的相互作用。

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~