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  3. HIT219539795
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HIT219539795
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HIT219539795
  • HIT ID:HIT219539795
  • Cas No:1314801-63-2
  • 常用名:AT-1001
  • IUPAC:(1R,3r,5S)-N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine
    IUPAC:(1R,3r,5S)-N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine
  • InChI key:UZJWAFOJOSGEKL-CLLJXQQHSA-N
  • 分子式:C15H21BrN2
  • 分子量:309.251
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:[H][C@]12CCC[C@]([H])(C[C@@H](C1)Nc1ccccc1Br)N2C
    SMILES:[H][C@]12CCC[C@]([H])(C[C@@H](C1)Nc1ccccc1Br)N2C
  • AT-1001 is an α3β4 nAChR partial agonist. AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats. AT-1001 also potently and reversibly blocks epibatidine-induced inward currents in HEK cells transfected with α3β4 nAChR. Importantly, AT-1001 potently and dose-dependently blocks nicotine self-administration in rats, without affecting food responding. When tested in a nucleus accumbens (NAcs) synaptosomal preparation, AT-1001 inhibits nicotine-induced [³H]dopamine release poorly and at significantly higher concentrations compared with mecamylamine and conotoxin MII.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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