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  3. HIT219539808
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HIT219539808
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HIT219539808
  • HIT ID:HIT219539808
  • Cas No:1417742-86-9
  • 常用名:CR-6086
  • IUPAC:4-[1-(6-{[4-(trifluoromethyl)phenyl]methyl}-6-azaspiro[2.5]octane-5-amido)cyclopropyl]benzoic acid
    IUPAC:4-[1-(6-{[4-(trifluoromethyl)phenyl]methyl}-6-azaspiro[2.5]octane-5-amido)cyclopropyl]benzoic acid
  • InChI key:CADWTPLFEZSAHM-UHFFFAOYSA-N
  • 分子式:C26H27F3N2O3
  • 分子量:472.508
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:OC(=O)c1ccc(cc1)C1(CC1)NC(=O)C1CC2(CC2)CCN1Cc1ccc(cc1)C(F)(F)F
    SMILES:OC(=O)c1ccc(cc1)C1(CC1)NC(=O)C1CC2(CC2)CCN1Cc1ccc(cc1)C(F)(F)F
  • CR6086 is a novel, potent EP4 antagonist showing favourable immunomodulatory properties, striking DMARD effects in rodents, and anti-inflammatory activity targeted to immune-mediated inflammatory diseases and distinct from the general effects of cyclooxygenase inhibitors. CR6086 showed selectivity and high affinity for the human EP4 receptor (Ki = 16.6 nM) and functioned as a pure antagonist (half-maximal inhibitory concentration, 22 nM) on PGE2-stimulated cAMP production.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    8-10周
    纯度
    -
    ¥ 15,000.00
    1

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